閮芥绉戞櫘涓ㄦ柊鍨嬪績鑴戣绠＄柧鐥呴璀︽爣璁帮細TMAO
鍙戝竷鏃堕棿锛
2023-05-04
鏉ユ簮锛
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鍥?锛?990-2018骞翠腑鍥藉煄涔″眳姘戝績鑴戣绠＄梾姝讳骸鐜囧彉鍖朁sup>[1]
鎴戝浗蹇冭剳琛€绠＄柧鐥呮偅鑰呭熀鏁颁粛鍦ㄤ笉鏂墿澶э紝闃叉帶宸ヤ綔闈复宸ㄥぇ鎸戞垬銆傛參鐥?ldquo;闃?rdquo;澶т簬“娌?rdquo;锛屾參鐥呴槻娌婚€愭笎浠?ldquo;娌诲凡鐥?rdquo;鍚?ldquo;娌绘湭鐥?rdquo;杞彉锛岀簿鍑嗘湁鏁堝湴鎵惧嚭鎺у埗涓綋鎱㈢梾鍙戝睍鐨勭浉鍏冲洜绱狅紝鍋氬ソ椋庨櫓棰勮锛屽彲杈呭姪鍖荤敓涓村簥璇婃柇锛屾彁楂樺尰鐤楁湇鍔¤川閲忥紝鎺ㄥ姩鐤剧梾闃叉不鍙栧緱鏂版垚鏁堛€侟/span>
澶ч噺鐮旂┒鏄剧ず锛孴MAO锛堟哀鍖栦笁鐢茶兒锛変笌蹇冭剳琛€绠＄柧鐥呯殑鍙戠梾椋庨櫓瀵嗗垏鐩稿叧銆俆MAO浣滀负涓€绉嶈偁閬撹弻缇ょ殑閲嶈浠ｈ阿浜х墿锛屽凡闄嗙画琚玁 Engl J Med銆丯ature绛夐《绾ф湡鍒婃姤閬撳叾涓村簥杈呭姪璇婃柇浠峰€笺€侟/span>
浜轰綋琛€娴嗕腑TMAO姘村钩鐨勫崌楂樹笌涓昏涓嶈壇蹇冭绠′簨浠讹紙MACE锛夐闄╁鍔?.5鍊嶆湁鍏筹紝鍏锋湁鐙珛棰勬祴浠峰€稽sup>[2]銆備竴椤硅崯钀冨垎鏋愭樉绀猴紝TMAO姣忓鍔?0μmol/L锛堢害750 ng/mL锛夛紝蹇冭绠＄柧鐥呮浜＄殑鐩稿椋庨櫓灏变細澧炲姞7.6%銆侟/span>
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鍥?锛歍MAO鐨勪唬璋㈤€氳矾
鍦═MAO涓庣柧鐥呯殑鍏宠仈搴︾爺绌舵柟闈紝閮芥鐢熺墿瀛愬叕鍙搁暱娌欓兘姝ｅ尰瀛︽楠屾湁闄愯矗浠诲叕鍙革紙绠€绉?ldquo;閮芥妫€楠?rdquo;锛夌Н绱繁鍘氾紝瀹屾垚鍗佷綑椤筎MAO鍙戞槑涓撳埄鐨勭敵璇峰拰鎺堟潈锛屽舰鎴愪簡鍥藉唴绗竴銆佸叏鐞冪浜岀殑TMAO涓撳埄闆嗙兢銆侟/span>
閮芥妫€楠孅/strong>
“閮芥妫€楠?rdquo;閲嶇偣寮€灞曪細鑲跨槫鏃╂湡绛涙煡鍙婇鍚庡垽鏂?鏂扮敓鍎块仐浼犱唬璋㈢梾绛涙煡/鑽墿娴撳害鐩戞祴/涓綋鍖栫敤鑽寚瀵?鍒嗗瓙鐥呯悊/鑽墿鍩哄洜缁勫鐮旂┒/鑲跨槫闈跺悜鑽浉鍏冲熀鍥犳娴?閲嶅ぇ鐤剧梾鐢熺墿鏍囧織鐗╃瓫鏌?浠ｈ阿缁勫鐮旂┒绛夋牳蹇冧笟鍔°€侟/span>
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TMAO浜旇仈妫€
鐮旂┒琛ㄦ槑锛孴MAO涓嶄粎鏄績琛€绠＄柧鐥呯殑閲嶈棰勬祴鍥犲瓙锛屼篃鏄寘鎷硸灏跨梾銆佽倽鑲剧柧鐥呭湪鍐呯殑澶氱鎱㈡€х柧鐥呯殑椋庨櫓鍥犲瓙銆侟/span>
姘у寲涓夌敳鑳猴紙TMAO锛夈€佷笁鐢茶兒锛圱MA锛夈€佽儐纰憋紙Choline锛夈€佺敎鑿滅⒈锛圔etaine锛夊拰鑲夌⒈锛圕arnitine锛夋槸纾疯剛閰拌儐纰变唬璋㈤€氳矾鐨勯噸瑕佺敓鐗╂爣蹇楃墿銆傞€氳繃鑱斿悎TMAO浠ｈ阿閫氳矾杩涚▼涓殑鐩稿叧鏍囧織鐗╋紝鍙敤浜庡績琛€绠￠闄╅娴嬨€佸啝鐘跺姩鑴夌‖鍖栥€佸績鍔涜“绔€佹參鎬ц偩鐥呫€佸濞犵硸灏跨梾绛夌柧鐥呯殑涓村簥杈呭姪鍒ゆ柇銆侟/span>
鍥?锛歍MAO浜旇仈妫€鍙婂叾鑱旀璐ㄨ氨鍥近/span>
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閮芥妫€楠屽凡涓庡瀹跺尰闄㈠悎浣滃紑灞昑MAO绛夋爣蹇楃墿妫€娴嬶紝鐩墠宸茬疮璁″畬鎴怲MAO鍗曟10000浣欎緥锛孴MAO鏍囧織鐗╄仈妫€600澶氫緥锛屽舰鎴愪簡鍏锋湁鍖哄煙鐗硅壊鐨凾MAO鍙婂叾浠ｈ阿閫氳矾鏍囧織鐗╄仈鍚堟娴嬫湇鍔★紝涓轰复搴婇」鐩鐮斻€佹參鐥呴璀︺€佷复搴婃不鐤楁柟妗堣皟鏁寸瓑鎻愪緵鑹ソ鐨勬暟鎹敮鎾戙€侟/span>
鍚堜綔鍜ㄨ锛欬/strong>0731-89786956杞?025
鈼 鍙傝€冩枃鐚?/strong>
[1]涓浗蹇冭绠″仴搴蜂笌鐤剧梾鎶ュ憡缂栧啓缁?涓浗蹇冭绠″仴搴蜂笌鐤剧梾鎶ュ憡2020姒傝. 涓浗寰幆鏉傚織, 2021, 36: 562-586.
[2] Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. N Engl J Med, 2013,368(17).